A significant body of literature evidences frequent comorbidity between substance misuse and psychosis. Both problems typically develop early and tremendously impact the quality of life and health of those who suffer from them. The nature of the relationship between substance misuse and psychosis seems to be intricate and interdependent. For example, research shows that prior cannabis use increases the incidence and poor prognosis of first-episode psychosis. On the other hand, many individuals with psychosis frequently misuse substances such as nicotine, cocaine and cannabis. In general, those who present co-occurring misuse experience poorer functioning, higher symptom severity and a greater risk of relapse. Thus, clarifying the links between addictions and psychosis would have a tremendous impact in terms of prevention and treatment effectiveness.
This PhD fellowship will explore the critical topic of shared risk factors and causal mechanisms between substance misuse and psychosis. By determining shared risk factors, we can effectively develop screening strategies to identify high-risk individuals earlier. In addition, we can recognise highly relevant therapeutic targets by exploring shared causal mechanisms and establishing more effective individually-tailored intervention strategies.
